CFTR REVIEW  PAGE

Amino Acid Sequence                   cDNA Sequence


AMINO ACID  SEQUENCE  

SEQUENCE 1480 AA; 168173 MW

MQRSPLEKAS      VVSKLFFSWT      RPILRKGYRQ      RLELSDIYQI       

PSVDSADNLS       EKLEREWDRE      LASKKNPKLI     NALRRCFFWR    

FMFYGIFLYL        GEVTKAVQPL      LLGRIIASYD        PDNKEERSIA     

IYLGIGLCLL          FIVRTLLLHP         AIFGLHHIGM       QMRIAMFSLI    

YKKTLKLSSR       VLDKISIGQL        VSLLSNNLNK     FDEGLALAHF    

VWIAPLQVAL       LMGLIWELLQ       ASAFCGLGFL      IVLALFQAGL   

GRMMMKYRDQ   RAGKISERLV        ITSEMIENIQ        SVKAYCWEEA 

MEKMIENLRQ       TELKLTRKAA      YVRYFNSSAF      FFSGFFVVFL   

SVLPYALIKG          IILRKIFTTI           SFCIVLRMAV      TRQFPWAVQT 

WYDSLGAINK        IQDFLQKQEY     KTLEYNLTTT      EVVMENVTAF  

WEEGFGELFE         KAKQNNNNRK  TSNGDDSLFF       SNFSLLGTPV  

LKDINFKIER          GQLLAVAGST     GAGKTSLLMM      IMGELEPSEG  

KIKHSGRISF          CSQFSWIMPG     TIKENIIFGV          SYDEYRYRSV  

IKACQLEEDI          SKFAEKDNIV      LGEGGITLSG       GQRARISLAR    

AVYKDADLYL      LDSPFGYLDV      LTEKEIFESC        VCKLMANKTR 

ILVTSKMEHL        KKADKILILH       EGSSYFYGTF       SELQNLQPDF   

SSKLMGCDSF       DQFSAERRNS     ILTETLHRFS         LEGDAPVSWT   

ETKKQSFKQT      GEFGEKRKNS      ILNPINSIRK        FSIVQKTPLQ

MNGIEEDSDE       PLERRLSLVP        DSEQGEAILP       RISVISTGPT

LQARRRQSVL      NLMTHSVNQG    QNIHRKTTAS      TRKVSLAPQA

NLTELDIYSR        RLSQETGLEI         SEEINEEDLK       ECFFDDMESI

PAVTTWNTYL     RYITVHKSLI         FVLIWCLVIF       LAEVAASLVV

LWLLGNTPLQ     DKGNSTHSRN      NSYAVIITST       SSYYVFYIYV

GVADTLLAMG    FFRGLPLVHT        LITVSKILHH       KMLHSVLQAP

MSTLNTLKAG     GILNRFSKDI         AILDDLLPLT      IFDFIQLLLI

VIGAIAVVAV      LQPYIFVATV        PVIVAFIMLR      AYFLQTSQQL

KQLESEGRSP       IFTHLVTSLK        GLWTLRAFGR    QPYFETLFHK

ALNLHTANWF    LYLSTLRWFQ      MRIEMIFVIF       FIAVTFISIL

TTGEGEGRVG     IILTLAMNIM         STLQWAVNSS    IDVDSLMRSV

SRVFKFIDMP      TEGKPTKSTK      PYKNGQLSKV    MIIENSHVKK

DDIWPSGGQM    TVKDLTAKYT      EGGNAILENI      SFSISPGQRV

GLLGRTGSGK      STLLSAFLRL        LNTEGEIQID      GVSWDSITLQ

QWRKAFGVIP     QKVFIFSGTF       RKNLDPYEQW   SDQEIWKVAD

EVGLRSVIEQ       FPGKLDFVLV      DGGCVLSHGH    KQLMCLARSV

LSKAKILLLD       EPSAHLDPVT      YQIIRRTLKQ       AFADCTVILC

EHRIEAMLEC      QQFLVIEENK      VRQYDSIQKL      LNERSLFRQA

ISPSDRVKLF       PHRNSSKCKS     KPQIAALKEE       TEEEVQDTRL

 

 

 


CFTR  cDNA  Sequence

LOCUS       HUMCFTRM     6129 bp    mRNA            PRI       27-APR-1993
DEFINITION  Human cystic fibrosis mRNA, encoding a presumed transmembrane
            conductance regulator (CFTR).
ACCESSION   M28668
NID         g180331
VERSION     M28668.1  GI:180331
KEYWORDS    cystic fibrosis; transmembrane conductance regulator.
SOURCE      Human, cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
            Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6129)
  AUTHORS   Riordan,J.R., Rommens,J.M., Kerem,B., Alon,N., Rozmahel,R.,
            Grzelczak,Z., Zielenski,J., Lok,S., Plavsic,N., Chou,J.-L.,
            Drumm,M.L., Iannuzzi,M.C., Collins,F.S. and Tsui,L.-C.
  TITLE     Identification of the cystic fibrosis gene: Cloning and
            characterization of complementary DNA
  JOURNAL   Science 245, 1066-1073 (1989)
  MEDLINE   89368940
COMMENT     A three base-pair deletion spanning positions 1654-1656 is observed
            in cDNAs from cystic fibrosis patients.
FEATURES             Location/Qualifiers
     source          1..6129
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
     CDS             133..4575
                     /note="cystic fibrosis transmembrane conductance
                     regulator"
                     /codon_start=1
                     /protein_id="AAA35680.1"
                     /db_xref="PID:g180332"
                     /db_xref="GI:180332"
                     
BASE COUNT     1886 a   1181 c   1330 g   1732 t
ORIGIN      
        1 aattggaagc aaatgacatc acagcaggtc agagaaaaag ggttgagcgg caggcaccca
       61 gagtagtagg tctttggcat taggagcttg agcccagacg gccctagcag ggaccccagc
      121 gcccgagaga ccatgcagag gtcgcctctg gaaaaggcca gcgttgtctc caaacttttt
      181 ttcagctgga ccagaccaat tttgaggaaa ggatacagac agcgcctgga attgtcagac
      241 atataccaaa tcccttctgt tgattctgct gacaatctat ctgaaaaatt ggaaagagaa
      301 tgggatagag agctggcttc aaagaaaaat cctaaactca ttaatgccct tcggcgatgt
      361 tttttctgga gatttatgtt ctatggaatc tttttatatt taggggaagt caccaaagca
      421 gtacagcctc tcttactggg aagaatcata gcttcctatg acccggataa caaggaggaa
      481 cgctctatcg cgatttatct aggcataggc ttatgccttc tctttattgt gaggacactg
      541 ctcctacacc cagccatttt tggccttcat cacattggaa tgcagatgag aatagctatg
      601 tttagtttga tttataagaa gactttaaag ctgtcaagcc gtgttctaga taaaataagt
      661 attggacaac ttgttagtct cctttccaac aacctgaaca aatttgatga aggacttgca
      721 ttggcacatt tcgtgtggat cgctcctttg caagtggcac tcctcatggg gctaatctgg
      781 gagttgttac aggcgtctgc cttctgtgga cttggtttcc tgatagtcct tgcccttttt
      841 caggctgggc tagggagaat gatgatgaag tacagagatc agagagctgg gaagatcagt
      901 gaaagacttg tgattacctc agaaatgatt gaaaatatcc aatctgttaa ggcatactgc
      961 tgggaagaag caatggaaaa aatgattgaa aacttaagac aaacagaact gaaactgact
     1021 cggaaggcag cctatgtgag atacttcaat agctcagcct tcttcttctc agggttcttt
     1081 gtggtgtttt tatctgtgct tccctatgca ctaatcaaag gaatcatcct ccggaaaata
     1141 ttcaccacca tctcattctg cattgttctg cgcatggcgg tcactcggca atttccctgg
     1201 gctgtacaaa catggtatga ctctcttgga gcaataaaca aaatacagga tttcttacaa
     1261 aagcaagaat ataagacatt ggaatataac ttaacgacta cagaagtagt gatggagaat
     1321 gtaacagcct tctgggagga gggatttggg gaattatttg agaaagcaaa acaaaacaat
     1381 aacaatagaa aaacttctaa tggtgatgac agcctcttct tcagtaattt ctcacttctt
     1441 ggtactcctg tcctgaaaga tattaatttc aagatagaaa gaggacagtt gttggcggtt
     1501 gctggatcca ctggagcagg caagacttca cttctaatga tgattatggg agaactggag
     1561 ccttcagagg gtaaaattaa gcacagtgga agaatttcat tctgttctca gttttcctgg
     1621 attatgcctg gcaccattaa agaaaatatc atctttggtg tttcctatga tgaatataga
     1681 tacagaagcg tcatcaaagc atgccaacta gaagaggaca tctccaagtt tgcagagaaa
     1741 gacaatatag ttcttggaga aggtggaatc acactgagtg gaggtcaacg agcaagaatt
     1801 tctttagcaa gagcagtata caaagatgct gatttgtatt tattagactc tccttttgga
     1861 tacctagatg ttttaacaga aaaagaaata tttgaaagct gtgtctgtaa actgatggct
     1921 aacaaaacta ggattttggt cacttctaaa atggaacatt taaagaaagc tgacaaaata
     1981 ttaattttga atgaaggtag cagctatttt tatgggacat tttcagaact ccaaaatcta
     2041 cagccagact ttagctcaaa actcatggga tgtgattctt tcgaccaatt tagtgcagaa
     2101 agaagaaatt caatcctaac tgagacctta caccgtttct cattagaagg agatgctcct
     2161 gtctcctgga cagaaacaaa aaaacaatct tttaaacaga ctggagagtt tggggaaaaa
     2221 aggaagaatt ctattctcaa tccaatcaac tctatacgaa aattttccat tgtgcaaaag
     2281 actcccttac aaatgaatgg catcgaagag gattctgatg agcctttaga gagaaggctg
     2341 tccttagtac cagattctga gcagggagag gcgatactgc ctcgcatcag cgtgatcagc
     2401 actggcccca cgcttcaggc acgaaggagg cagtctgtcc tgaacctgat gacacactca
     2461 gttaaccaag gtcagaacat tcaccgaaag acaacagcat ccacacgaaa agtgtcactg
     2521 gcccctcagg caaacttgac tgaactggat atatattcaa gaaggttatc tcaagaaact
     2581 ggcttggaaa taagtgaaga aattaacgaa gaagacttaa aggagtgcct ttttgatgat
     2641 atggagagca taccagcagt gactacatgg aacacatacc ttcgatatat tactgtccac
     2701 aagagcttaa tttttgtgct aatttggtgc ttagtaattt ttctggcaga ggtggctgct
     2761 tctttggttg tgctgtggct ccttggaaac actcctcttc aagacaaagg gaatagtact
     2821 catagtagaa ataacagcta tgcagtgatt atcaccagca ccagttcgta ttatgtgttt
     2881 tacatttacg tgggagtagc cgacactttg cttgctatgg gattcttcag aggtctacca
     2941 ctggtgcata ctctaatcac agtgtcgaaa attttacacc acaaaatgtt acattctgtt
     3001 cttcaagcac ctatgtcaac cctcaacacg ttgaaagcag gtgggattct taatagattc
     3061 tccaaagata tagcaatttt ggatgacctt ctgcctctta ccatatttga cttcatccag
     3121 ttgttattaa ttgtgattgg agctatagca gttgtcgcag ttttacaacc ctacatcttt
     3181 gttgcaacag tgccagtgat agtggctttt attatgttga gagcatattt cctccaaacc
     3241 tcacagcaac tcaaacaact ggaatctgaa ggcaggagtc caattttcac tcatcttgtt
     3301 acaagcttaa aaggactatg gacacttcgt gccttcggac ggcagcctta ctttgaaact
     3361 ctgttccaca aagctctgaa tttacatact gccaactggt tcttgtacct gtcaacactg
     3421 cgctggttcc aaatgagaat agaaatgatt tttgtcatct tcttcattgc tgttaccttc
     3481 atttccattt taacaacagg agaaggagaa ggaagagttg gtattatcct gactttagcc
     3541 atgaatatca tgagtacatt gcagtgggct gtaaactcca gcatagatgt ggatagcttg
     3601 atgcgatctg tgagccgagt ctttaagttc attgacatgc caacagaagg taaacctacc
     3661 aagtcaacca aaccatacaa gaatggccaa ctctcgaaag ttatgattat tgagaattca
     3721 cacgtgaaga aagatgacat ctggccctca gggggccaaa tgactgtcaa agatctcaca
     3781 gcaaaataca cagaaggtgg aaatgccata ttagagaaca tttccttctc aataagtcct
     3841 ggccagaggg tgggcctctt gggaagaact ggatcaggga agagtacttt gttatcagct
     3901 tttttgagac tactgaacac tgaaggagaa atccagatcg atggtgtgtc ttgggattca
     3961 ataactttgc aacagtggag gaaagccttt ggagtgatac cacagaaagt atttattttt
     4021 tctggaacat ttagaaaaaa cttggatccc tatgaacagt ggagtgatca agaaatatgg
     4081 aaagttgcag atgaggttgg gctcagatct gtgatagaac agtttcctgg gaagcttgac
     4141 tttgtccttg tggatggggg ctgtgtccta agccatggcc acaagcagtt gatgtgcttg
     4201 gctagatctg ttctcagtaa ggcgaagatc ttgctgcttg atgaacccag tgctcatttg
     4261 gatccagtaa cataccaaat aattagaaga actctaaaac aagcatttgc tgattgcaca
     4321 gtaattctct gtgaacacag gatagaagca atgctggaat gccaacaatt tttggtcata
     4381 gaagagaaca aagtgcggca gtacgattcc atccagaaac tgctgaacga gaggagcctc
     4441 ttccggcaag ccatcagccc ctccgacagg gtgaagctct ttccccaccg gaactcaagc
     4501 aagtgcaagt ctaagcccca gattgctgct ctgaaagagg agacagaaga agaggtgcaa
     4561 gatacaaggc tttagagagc agcataaatg ttgacatggg acatttgctc atggaattgg
     4621 agctcgtggg acagtcacct catggaattg gagctcgtgg aacagttacc tctgcctcag
     4681 aaaacaagga tgaattaagt ttttttttaa aaaagaaaca tttggtaagg ggaattgagg
     4741 acactgatat gggtcttgat aaatggcttc ctggcaatag tcaaattgtg tgaaaggtac
     4801 ttcaaatcct tgaagattta ccacttgtgt tttgcaagcc agattttcct gaaaaccctt
     4861 gccatgtgct agtaattgga aaggcagctc taaatgtcaa tcagcctagt tgatcagctt
     4921 attgtctagt gaaactcgtt aatttgtagt gttggagaag aactgaaatc atacttctta
     4981 gggttatgat taagtaatga taactggaaa cttcagcggt ttatataagc ttgtattcct
     5041 ttttctctcc tctccccatg atgtttagaa acacaactat attgtttgct aagcattcca
     5101 actatctcat ttccaagcaa gtattagaat accacaggaa ccacaagact gcacatcaaa
     5161 atatgcccca ttcaacatct agtgagcagt caggaaagag aacttccaga tcctggaaat
     5221 cagggttagt attgtccagg tctaccaaaa atctcaatat ttcagataat cacaatacat
     5281 cccttacctg ggaaagggct gttataatct ttcacagggg acaggatggt tcccttgatg
     5341 aagaagttga tatgcctttt cccaactcca gaaagtgaca agctcacaga cctttgaact
     5401 agagtttagc tggaaaagta tgttagtgca aattgtcaca ggacagccct tctttccaca
     5461 gaagctccag gtagagggtg tgtaagtaga taggccatgg gcactgtggg tagacacaca
     5521 tgaagtccaa gcatttagat gtataggttg atggtggtat gttttcaggc tagatgtatg
     5581 tacttcatgc tgtctacact aagagagaat gagagacaca ctgaagaagc accaatcatg
     5641 aattagtttt atatgcttct gttttataat tttgtgaagc aaaatttttt ctctaggaaa
     5701 tatttatttt aataatgttt caaacatata ttacaatgct gtattttaaa agaatgatta
     5761 tgaattacat ttgtataaaa taatttttat atttgaaata ttgacttttt atggcactag
     5821 tatttttatg aaatattatg ttaaaactgg gacaggggag aacctagggt gatattaacc
     5881 aggggccatg aatcaccttt tggtctggag ggaagccttg gggctgatcg agttgttgcc
     5941 cacagctgta tgattcccag ccagacacag cctcttagat gcagttctga agaagatggt
     6001 accaccagtc tgactgtttc catcaagggt acactgcctt ctcaactcca aactgactct
     6061 taagaagact gcattatatt tattactgta agaaaatatc acttgtcaat aaaatccata
     6121 catttgtgt
//
 
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